basic FUNCTION
| may have a role in signal-induced cytoskeletal regulation and/or endocytosis |
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involved in metabolic regulation, cardiac and brain function, senescence regulated secretion, mitogenesis and cytoskeletal changes |
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implicated in the regulation of Ca(2+) mobilization and contractile performance in the heart |
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may have a role in signal-induced cytoskeletal regulation and/or endocytosis |
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play a key role in the regulation of agonist-induced endocytosis of the mu-opioid receptor |
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PLD1, PLD2 activity plays an important role in promoting IgE-dependent signaling events within lipid microdomains in mast cells |
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overexpression leads to an increased DNA synthesis in presence of CD45 phosphatase |
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required for the stimulation of lysophosphatidic acid production by EGF |
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agonist-selective activation plays a key role in the regulation of NADH/NADPH-mediated ROS formation by opioids |
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both PLD1 and PLD2 participate in regulated cellular secretion, cytoskeletal organization, gene expression regulation, cell cycle control, growth, proliferation, and differentiation |
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involved in the subcellular localization of formyl-peptide receptors |
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phosphorylated PLD2, aided by Grb2, mediates lipase activity, whereas dephosphorylated PLD2 mediates an induction of cell proliferation |
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in activated cells PLD2 affects RAC2 in an initial positive feedback, but as RAC2-GTP accumulates in the cell, this constitutes a termination signal leading to PLD2 inactivation |
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PLD2 and FES might be physically associated, which could be beneficial for a quick transduction of the activating signal within the cell |
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PLD1, PLD2 shortens the differentiation time of cells becoming mature neutrophils |
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producing phosphatidic acid (PA) that plays an important role in regulating cell morphology in mast cells |
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involvement of PLD2 and phosphatidic acid (PA) in mediating PARN-induced eukaryotic mRNA decay and the crosstalk between the two enzymes that is deregulated in breast cancer cells |