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FLASH GENE

Symbol

DLG2

contributors: mct - updated : 10-03-2022

HGNC name	discs, large homolog 2, chapsyn-110 (Drosophila)
HGNC id	2901

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       missense variant (F900V) in DLG2 (which encodes DLG2) that cosegregated with the delayed puberty constitutional   deletion     partial deletion of the DLG2 gene in patients with global developmental delay and intellectual disability

Susceptibility

to schizophrenia Parkinson's disease (PD)

Variant & Polymorphism other	copy number variants indicating loss of function in the DLG2 gene have been associated with markedly increased risk for schizophrenia, autism spectrum disorder, and intellectual disability
	DLG2 rs3793947 AA genotype showed a significantly lower prevalence in female PD patients compared to the female controls

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer overexpression of DLG2 might be a potential therapy for AD

ANIMAL & CELL MODELS

Dlg2+/- rats had reduced supra-linear dendritic integration of synaptic inputs resulting in impaired associative long-term potentiation