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FLASH GENE
Symbol KIF1C contributors: mct/npt/shn - updated : 28-12-2018
HGNC name kinesin family member 1C
HGNC id 6317
ASSOCIATED DISORDERS
corresponding disease(s) SPAX2
Susceptibility to autoimmune orchitis
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • kif1C(-/-) mice are viable and showed no obvious abnormalities
  • no significant difference in the distribution of the Golgi apparatus or in the transport from the Golgi apparatus to the endoplasmic reticulum in fibroblasts from kif1C(-/-) mice
  • Expression of mutation constructs or small interfering RNA-/short hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency