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FLASH GENE
Symbol KIF1C contributors: mct/npt/shn - updated : 28-12-2018
HGNC name kinesin family member 1C
HGNC id 6317
DNA
TYPE functioning gene
STRUCTURE 26.72 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure
  • conserved essential regulatory element in the kinesin-1 tail interacts directly and specifically with the enzymatically critical Switch I region of the head
  • MAPPING cloned Y linked N status provisional
    Map pter - D17S1828 - D17S1584 - KIF1C - D17S1810 - D17S1854 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 7935 135 1103 - - 9685376
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdultNM_006612
    Digestiveliver   lowly Homo sapiensAdultNM_006612
    Endocrinepancreas   moderately Homo sapiensAdultNM_006612
    Nervousbrain   lowly Homo sapiensAdultNM_006612
    Reproductivefemale systemplacenta  moderately Homo sapiensAdultNM_006612
    Respiratorylung   lowly Homo sapiensAdultNM_006612
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiensAdultNM_006612
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FHA domain
  • N terminal motor domain
  • PTPD-binding domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Kif1c
    homolog to C.elegans M116.5
    intraspecies homolog to kinesin-like motor protein KIF1 c
    Homologene
    FAMILY
  • Kinesin-3 family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    text Golgi apparatus and endoplasmic reticulum
    basic FUNCTION
  • act as microtubule-based molecular motors involved in intracellular transport
  • podosome regulation
  • microtubule motor KIF1C contributes to persistent cell migration primarily through stabilization of an extended cell rear
  • may likely be involved in transport around the Golgi apparatus rather than only Golgi-to-ER transport
  • the kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes
  • KIF1C is a player in the podosome-inducing signaling cascade
  • KIF1C can protect Golgi membranes from fragmentation in cells lacking an intact microtubule network
  • KIF1A or KIF1C must have an effect on the cycle of division before differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTPD1
  • transports RAB6A-vesicles and can influence Golgi complex organization
  • RAB6A binding to the motor domain inhibits microtubule interaction and in cells, decreasing the amount of motile KIF1C
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPAX2
    Susceptibility to autoimmune orchitis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • kif1C(-/-) mice are viable and showed no obvious abnormalities
  • no significant difference in the distribution of the Golgi apparatus or in the transport from the Golgi apparatus to the endoplasmic reticulum in fibroblasts from kif1C(-/-) mice
  • Expression of mutation constructs or small interfering RNA-/short hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency