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FLASH GENE

Symbol

ARHGAP26

contributors: mct - updated : 23-05-2015

HGNC name	Rho GTPase activating protein 26
HGNC id	17073

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     fusion with MLL in t(5;11)(q31;q23) in myelodysplastic syndrome tumoral   deletion     deletion in myelodysplastic syndrome tumoral       gain of function activated in malignant melanoma tumoral     --low   in myeloid malignancies constitutional     --low   decreased in ATRX patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

GrafF1-depleted embryos exhibited elevated RhoA activity and defective myofibrillogenesis that resulted in progressive muscle degeneration, defective motility, and embryonic lethality