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FLASH GENE

Symbol

ARHGAP26

contributors: mct - updated : 23-05-2015

HGNC name	Rho GTPase activating protein 26
HGNC id	17073

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	458.28 kb     23 Exon(s)

regulatory sequence	Promoter
	Binding site
text structure	two putative protein-binding sites are identified of which one was sensitive to CpG methylation

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135608 23 - 8876 NP_001129080 - 759 - 1999 9858476 NM_015071 23 - 9041 NP_055886 - 814 - 1999 9858476 variant 3 - - 448 - - predominant brain expression 2010 20602808

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Homo sapiens Digestive intestine large intestine colon   highly   mouth       predominantly   stomach       highly Nervous brain       highly Homo sapiens   nerve cranial nerve     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum cardiac   highly Homo sapiens Muscular striatum skeletal     Homo sapiens

cell lineage
cell lines
fluid/secretion	moderately in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal nuclear localization signal (NLS)
	a PH domain
	a GTPase activating protein (GAP) domain
	an amphipathic lipid bending/sculpting BAR domain
	a SH3 C-terminal domain

HOMOLOGY

interspecies	homolog to rattus Arhgap26 (97.8 pc)
	homolog to murine Arhgap26 (96.9 pc)

Homologene

FAMILY

Rho family of GTPase-activating protein (GAP) family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	acting as a negative regulator of Rho A
	GAP activity
	integrin signal transduction pathway
	might be involved in the pathogenesis of the mental retardation
	necessary and sufficient for mediating RHOA down-regulation and inducing muscle differentiation
	might serve as a key regulator of RHOA activity during myogenesis
	remodels potentially membrane microdomains at adhesion sites into endocytic carriers, facilitating membrane turnover during cell morphological changes
	is a regulator of clathrin-independent endocytosis
	its activity regulates polarity establishment

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

text	nervous system development
	actin cytoskeleton organization and biogenesis

PATHWAY

metabolism

signaling

signal transduction

critical component of the integrin signaling transduction pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to the C-terminal of pp125(FAK)
	promotes skeletal muscle differentiation by limiting RHOA/ROCK1 signaling
	interacted with a network of endocytic and adhesion proteins and enriched at podosome-like adhesions and src-induced podosomes
	ARHGAP26 -mediated removal of RAB8A from the cell surface restricts its activity during protrusion formation, thereby facilitating dynamic adjustment of the polarity axis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     fusion with MLL in t(5;11)(q31;q23) in myelodysplastic syndrome tumoral   deletion     deletion in myelodysplastic syndrome tumoral       gain of function activated in malignant melanoma tumoral     --low   in myeloid malignancies constitutional     --low   decreased in ATRX patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

GrafF1-depleted embryos exhibited elevated RhoA activity and defective myofibrillogenesis that resulted in progressive muscle degeneration, defective motility, and embryonic lethality