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FLASH GENE

Symbol

SEMA3E

contributors: mct/npt - updated : 07-06-2018

HGNC name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
HGNC id	10727

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CHARGE2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   expression inversely correlated with tumor progression, with no detectable staining in melanoma metastasis (Roodink 2008) tumoral     --over   in human pancreatic cancer, and that high SEMA3E levels are associated with tumor progression and poor survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a suitable prognostic marker for pancreatic cancer
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas therapeutic target for pancreatic cancer

ANIMAL & CELL MODELS