basic FUNCTION
| may be involved in development |
|
can function as potent anti-tumorigenic agents (but is required expression of appropriate semaphorin receptors by tumor cells) (Kigel 2008) |
|
novel role of SEMA3E-PLXND1 function in modulating angiogenesis via a VEGFA-induced feedback mechanism (pMID: 21724832) |
|
acts as a negative regulator of macrophage migration, which may promote macrophage retention and chronic inflammation |
|
SEMA3E, SEMA3D direct endothelial motility through distinct molecular signaling pathways |
|
SEMA3E controls cell migration and invasiveness in cancer cells |
|
SEMA3E could be considered an essential regulatory mediator involved in modulation of neutrophil migration throughout the course of neutrophilic inflammation |