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FLASH GENE
Symbol SEMA3E contributors: mct/npt - updated : 07-06-2018
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
HGNC id 10727
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 6474 - 775 - 2017 27913633
17 - 5993 - 715 - 2017 27913633
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
Nervousbrain    
Respiratoryrespiratory tracttrachea  highly
Visualeyeanterior segmentiris  
 eyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualganglion cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, cochlea
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SEMA domain
  • one immunoglobulin like C2 type domain
  • conjugated GlycoP
    mono polymer aggregate
    HOMOLOGY
    interspecies homolog to murine semaphorin H
    homolog to C.elegans Y54E5B.1
    Homologene
    FAMILY
  • semaphorin/collapsin family
  • CATEGORY secretory , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • may be involved in development
  • can function as potent anti-tumorigenic agents (but is required expression of appropriate semaphorin receptors by tumor cells) (Kigel 2008)
  • novel role of SEMA3E-PLXND1 function in modulating angiogenesis via a VEGFA-induced feedback mechanism (pMID: 21724832)
  • acts as a negative regulator of macrophage migration, which may promote macrophage retention and chronic inflammation
  • SEMA3E, SEMA3D direct endothelial motility through distinct molecular signaling pathways
  • SEMA3E controls cell migration and invasiveness in cancer cells
  • SEMA3E could be considered an essential regulatory mediator involved in modulation of neutrophil migration throughout the course of neutrophilic inflammation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • SEMA3E-PLXND1 signaling is involved in the development of choroidal neovascularization (CNV)
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of PLXND1 (interacting during the formation of proprioceptive sensory–motor reflex circuits) (Pecho-Vrieseling 2009)
  • IQSEC1 mediates SEMA3E-induced ARF6 activation in endothelial cells
  • SEMA3E acts as a chemoattractant for macrophages, with TP53-induced upregulation of SEMA3E expression provoking adipose tissue inflammation and systemic insulin resistance in association with dietary obesity
  • SH3BP1 mediates SEMA3E-induced cell collapse through interaction with PLXND1 and regulation RAC1 activity
  • SEMA3E is an essential gene for GNRH1 neuron development
  • SEMA3E/PLXND1 modulates Immunological synapse (IS) formation and Ag-scanning activities of thymocytes within thymic tissues
  • RORA is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CHARGE2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    expression inversely correlated with tumor progression, with no detectable staining in melanoma metastasis (Roodink 2008)
    tumoral     --over  
    in human pancreatic cancer, and that high SEMA3E levels are associated with tumor progression and poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a suitable prognostic marker for pancreatic cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    therapeutic target for pancreatic cancer
    ANIMAL & CELL MODELS