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FLASH GENE

Symbol

IRF7

contributors: mct/ - updated : 30-01-2018

HGNC name	interferon regulatory factor 7
HGNC id	6122

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD39

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   most lung cells from stable Chronic Obstructive Pulmonary Disease (COPD) patients show a constitutive decreased expression of IFNB1, IRF7, DDX58 and IFIH1, suggesting that this deficiency is the main cause of their acute viral exacerbations

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous vascular   may represent a promising target for vascular disease therapy

ANIMAL & CELL MODELS

Irf7-null mice are consistently more vulnerable than Myd88-null mice to viral infection, and this correlated with marked decrease in serum interferon levels, indicating the importance of the IRF7-dependent induction of systemic interferon responses for innate antiviral immunity