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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

MACF1

contributors: mct/npt - updated : 30-08-2018

HGNC name	microtubule-actin crosslinking factor 1
HGNC id	13664

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LDHCC

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       causes a novel myopathy genetic disease constitutional       loss of function abolishes ciliogenesis and disrupts apicobasal polarity establishment in the retina

Susceptibility

Variant & Polymorphism

Candidate gene	ZFHX3, MACF1, RBM15, and SETD2 are Orofacial cleft candidate risk genes
Marker
Therapy target
	System Type Disorder Pubmed cancer     potential target to enhance the efficacy of therapeutic treatment modalities in cancers cancer brain glioma/neuroblstoma potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas

ANIMAL & CELL MODELS