| Symbol
| ALDH1A1
| contributors: mct/npt - updated : 29-11-2023
|
| HGNC name
| aldehyde dehydrogenase 1 family, member A1
|
| HGNC id
| 402
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
in non small cell lung cancer  | | tumoral
|
|
| --over
|
| |
in acute myeloid leukemia patients of the poor prognosis risk group | |
| Susceptibility
|
to development of alcohol and other substance use disorders |
| Variant & Polymorphism
other
| ALDH1A1*2 may be associated with protection from the development of alcohol and other substance use disorders |
| 
|
| Candidate gene
| activation of ALDH1A1, which efficiently catalyzes the detoxification of lipid-derived toxic aldehydes, and/or prevention of its oxidative modification may be novel therapeutic interventions against oxidative stress-induced lens pathologies |
|
could be a prostate cancer stem cells-related marker (measuring its expression might provide a potential approach to study tumorigenesis of prostate cancer and predict outcome of the disease)(Li 2010) |
Marker
Therapy target
|
| | |
|
| global elimination of Aldh1a1 and Aldh1a2 genes in mice blocks spermatogenesis but does not appear to affect viability | |
Aldh1a1-/- mice showed choroidal hypoplasia with insufficient vascularization in the dorsal region |