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FLASH GENE

Symbol

ZFP36

contributors: mct/npt/pgu - updated : 18-07-2016

HGNC name	zinc finger protein 36, C3H type, homolog (mouse)
HGNC id	12862

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   expression restricted to the cells in the synovial lining layer in rheumatoid arthritis constitutional     --over   its overexpression reduced the expression level of LATS2)

Susceptibility

to rheumatoid arthritis (RA) in African-Americans to Graves ophthalmopathy

Variant & Polymorphism SNP , other	polymorphisms increasing the risk of rheumatoid arthritis (RA) in African-Americans
	rs1057745 and rs11083522 in ZFP36 were associated with Graves ophthalmopathy

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice deficient in ttp