motifs/domains
| Kruppel-associated box at the N-terminus |
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two C3H1-type zinc fingers |
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a basic proline-rich domain |
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one KRAB domain |
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potential phosphorylation sites including the sequence PSPTSPT |
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three tetraproline repeats |
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a serine-rich region |
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a serine-phenylalanine "SFS" and an "arginine element " (RRLPIF) at the carboxyl terminus |
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a nuclear localization signal (NLS) |
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a nuclear export signal (NES) |
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conserved C-terminal motif in ZFP36 that directly binds a central domain of CNOT1, a core subunit of the CCR4-NOT complex |
basic FUNCTION
| inhibiting macrophage TNF-alpha production by destabilizing its mRNA |
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involved in regulating the response to growth factors |
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physiological regulator of GM-CSF mRNA deadenylation and stability |
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having a functional role of CCCH zinc finger genes in the regulation of macrophage activation |
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destabilizes a number of inflammatory mediators via its zinc finger-mediated interaction with AREs |
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AU-rich elements (ARE)-binding protein that promotes degradation of ARE-containing transcripts |
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involved in regulation of LATS2 transcript stability (may modulate the effect of this protein on cell proliferation) |
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involved in post-transcriptional regulation of BIRC3 expression |
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modulates macrophage inflammatory activity by destabilizing cytokine mRNAs |
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could control IL17-mediated inflammation |
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CCCH tandem zinc finger proteins that can bind to AU-rich elements in mRNAs and promote their decay |
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ZFAND5 and ZFP36 coordinately regulate many ARE-encoding proinflammatory genes at the level of mRNA decay |
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potential and hitherto unreported role of ZFP36 gene in kidney morphogenesis |
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RNA-binding protein that controls the inflammatory response by limiting the expression of several proinflammatory cytokines |
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ZFP36 plays an important role in RIPK1-dependent cell death in conditions where IAPs are depleted |
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regulates the expression of AU-rich element-containing mRNAs through promoting the degradation and repressing the translation of target mRNA |
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promotes translation repression and degradation of mRNAs containing AU-rich elements (AREs) |
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ZFP36, ZFP36L1, and ZFP36L2, regulates the production of growth factors and cytokines via destabilization of the respective mRNAs |
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both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner |
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ZFP36, ZFP36L1, and ZFP36L2, play key roles in the post-transcriptional regulation of gene expression |