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FLASH GENE

Symbol

NR4A3

contributors: mct - updated : 19-12-2013

HGNC name	nuclear receptor subfamily 4, group A, member 3
HGNC id	7982

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     in extraskeletal and skeletal myxoid chondrosarcoma EMC with t(9;22)(q22;q12) see EWS, EWSR, or t(9;17)(q22;q11),(see TAF2N) constitutional     --over   in coronary atherosclerosis, and in atherosclerotic plaques tumoral fusion       fused to TFG in myxoid chondrosarcoma tumoral     --other   aberrant coexpression with SIX3 is a potential alternative mechanism underlying the development of extraskeletal myxoid chondrosarcomas constitutional     --over   in human endothelial cells increased the expression of vascular cell adhesion molecule VCAM1 and intercellular adhesion molecule-1 tumoral     --low   of NR4A1 and NR4A3 was a common feature in leukemic blasts from human acute myeloid leukemia patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cellular extraskeletal myxoid chondrosarcoma
Therapy target
	System Type Disorder Pubmed cardiovascular     blockage of NR4A3 could be useful to prevent vascular effects triggered by thrombin cancer     identification of pro-apoptotic agents inducing NR4A expression or acting as agonists suggests that these members could serve as potential targets for cancer therapy

ANIMAL & CELL MODELS

	expression increased in diabetic mice that exhibit elevated gluconeogenesis
	Nor1 deficiency reduces hypercholesterolemia-induced atherosclerosis formation in apoE(-/-) mice by decreasing the macrophage content of the lesion