basic FUNCTION
| may be acting as a transcriptional activator |
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modulating vascular smooth muscle cell proliferation |
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playing a role in spontaneous and accelerated atherosclerosis |
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required for T-cells receptor mediated apoptosis of immature thymocytes |
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playing a necessary role for oxidative metabolism in skeletal muscle |
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its up-regulation plays a key role in thrombin-induced endothelial cell growth |
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mediating vascular smooth muscle cell proliferation |
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is involved in the regulation of the survival response of endothelial cells to hypoxia via the upregulation of CIAP2 |
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downstream effector of HIF-1 signaling |
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essential mediator of neuroprotection after exposure to neuropathological stress |
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key downstream mediator of CREB1-induced neuroprotection |
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mediates monocyte adhesion by inducing VCAM1 and intercellular adhesion molecule-1 expression in endothelial cells |
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induction of NR4A1, NR4A2, NR4A3 in activated mast cells and NR4A family nuclear receptors are implicated in the regulation of mast cell function |
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is a novel positive transcriptional regulator of SKP2 expression and downstream CDKN1B degradation in vascular smooth muscle cells |
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specific requirement of NR4A3 for SKP2 expression during neointima formation in response to vascular injury |
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NR4A1, NR4A2, NR4A3 have key roles in determining CD4(+) T cell fates in the thymus and thus contribute to immune homeostasis |
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NR4A1, NR4A2, NR4A3 are regulated by different physiological and pathophysiological settings known to be associated with marked alterations in glucose metabolism and energy status |