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FLASH GENE
Symbol ENPP2 contributors: mct/npt - updated : 16-04-2008
HGNC name ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
HGNC id 3357
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in clear cell renal carcinoma with good outcome
tumoral     --over  
in glioblastoma multiforme
constitutional     --over  
in frontal cortex of Alzheimer-type dementia patients
tumoral     --over  
in undifferentiated anaplastic thyroid carcinoma cell lines (UTC) and tumor tissues as compared to follicular thyroid carcinoma (FTC) cell lines
tumoral     --over  
with AGK, were frequently expressed in prostate cancer cells and precancerous high-grade intra-epithelial neoplasia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target a potential target of treatments for Alzheimer disease
ANIMAL & CELL MODELS