Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ENPP2 contributors: mct/npt - updated : 16-04-2008
HGNC name ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
HGNC id 3357
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal intracellular domain involved in the targeting to the plasma membrane
  • a single transmembrane domain
  • a large extracellular domain encompassing two consecutive somatomedin-B-like domains
  • a catalytic domain
  • a poorly characterized C-terminal domain
    • HOMOLOGY
    Homologene
    FAMILY
  • nucleotide pyrophosphatase/phosphodiesterase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type II transmembrane glycoprotein
    basic FUNCTION
  • phosphodiesterase I, brain type/nucleotide pyrophosphatase activity
  • type II ectonucleotide pyrophosphate phosphodiesterase enzymehaving a lysophospholipase D activity
  • augments invasive and metastatic potential of tumor cells
  • playing a critical role in vascular development
  • having a lysophospholipase D activity
  • plays a significant role in initiating and sustaining tumor metastasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in clear cell renal carcinoma with good outcome
    tumoral     --over  
    in glioblastoma multiforme
    constitutional     --over  
    in frontal cortex of Alzheimer-type dementia patients
    tumoral     --over  
    in undifferentiated anaplastic thyroid carcinoma cell lines (UTC) and tumor tissues as compared to follicular thyroid carcinoma (FTC) cell lines
    tumoral     --over  
    with AGK, were frequently expressed in prostate cancer cells and precancerous high-grade intra-epithelial neoplasia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target a potential target of treatments for Alzheimer disease
    ANIMAL & CELL MODELS