Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

CHRNA2

contributors: mct - updated : 07-12-2021

HGNC name	cholinergic receptor, nicotinic, alpha 2 (neuronal)
HGNC id	1956

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ENFL4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional somatic mutation     gain of function point mutation alpha2-I279N can be coexpressed with CHRNB2 and causes a marked gain of function effect (Hoda 2009)

Susceptibility

to nicotine dependence

Variant & Polymorphism other	significant association of CHRNA2 with nicotine dependence (ND)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

inactivation of Chrna2 in mice compromised the cold-induced thermogenic response selectively in subcutaneous fat and exacerbated high-fat diet-induced obesity and associated metabolic disorders