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FLASH GENE

Symbol

CHRNA2

contributors: mct - updated : 07-12-2021

HGNC name	cholinergic receptor, nicotinic, alpha 2 (neuronal)
HGNC id	1956

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N terminal extracellular domain
	two agonist binding sites
	four transmembrane segments (4TM)
	the M2 domain comprising the cation-selective pore

HOMOLOGY

interspecies

ortholog to murine Chrna2

Homologene

FAMILY	cholinergic receptor family
	ligand-gated ionic channel family

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION

leading to opening of an ion-conducting channel across the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component	two different types of subunits :
	alpha and non-alpha (beta)
	alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ENFL4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional somatic mutation     gain of function point mutation alpha2-I279N can be coexpressed with CHRNB2 and causes a marked gain of function effect (Hoda 2009)

Susceptibility

to nicotine dependence

Variant & Polymorphism other	significant association of CHRNA2 with nicotine dependence (ND)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

inactivation of Chrna2 in mice compromised the cold-induced thermogenic response selectively in subcutaneous fat and exacerbated high-fat diet-induced obesity and associated metabolic disorders