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FLASH GENE
Symbol MDK contributors: mct - updated : 21-10-2019
HGNC name midkine (neurite growth-promoting factor 2)
HGNC id 6972
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
in sporadic colorectal and gastric cancer
tumoral     --over  
in hepatocellular carcinomas
tumoral     --over  
in malignant peripheral nerve sheath tumor
constitutional     --over  
in autism spectrum disorder patients
constitutional     --over  
elevated plasma MDK and PTN levels in patients with systemic lupus erythematosus
constitutional       loss of function
exacerbates necrotizing glomerular injuries in progressive glomerulonephritis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • urinary midkine as a biomarker in patients with acute kidney injury
  • MDK and PTN growth factors might be likely useful as markers for infection in pregnancies
  • co-expression of MDK and PTN is significantly correlated with prognosis in glioma patients
  • high expression of MDK and SDC3 may contribute to the highly perineural invasion and poor prognosis of human pancreatic cancer
  • could be taken as an ideal diagnostic marker of acute leukemia
    • Therapy target
    SystemTypeDisorderPubmed
    tumor  
    specific inhibitors for MDK as part of new therapeutic concepts against MPNSTs (malignant peripheral nerve sheath tumor)
    immunologyautoimmune 
    is a promising therapeutic target for various autoimmune diseases
    osteoarticularboneostéoporosis
    MDK-specific antagonists might prove beneficial in osteoporosis therapy
    cancerhemopathy 
    could be taken as an ideal molecular target for the treatment of acute leukemia
    ANIMAL & CELL MODELS
  • Mdk-deficiency in mice has an anabolic effect on mechanically induced cortical bone formation