| basic FUNCTION
| essential for normal development of the catecholamine and renin-angiotensin pathways and the synthesis of different collagens |
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involved in nervous system development |
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mediator for intercellular transfer of drug resistance |
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promoting the migration of inflammatory leukocytes |
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playing important roles in the formation of intraperitoneal adhesions, at least partly by promoting the migration of macrophages and neutrophils to the omentum |
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implicated in the tumorigenesis of benign and plexiform neurofibromas, and therefore arising malignant peripheral nerve sheath tumors (MPNSTs) |
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factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the dopamine (DA) system  |
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may maintain normal adult brain as a neurotrophic factor, and MDK may be released from leucocytes in brain of patients with meningitis as an immunological mediator |
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may contribute to neuronal regeneration |
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promotes tumor growth mainly by inducing angiogenesis |
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MDK is a pivotal player of angiogenesis during ischemia in nonmalignant tissue |
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critical role for the MDK-NOTCH2 signaling axis in neuroblastoma tumorigenesis, which implicates new strategies to treat neuroblastoma |
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cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via beta2 integrins (CD11/CD18) |
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heparin-binding growth factor, which behaves like a cytokine, involved in various cellular processes such as cellular proliferation, differentiation, survival, adhesion, and migration |
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seems to be involved in the development of Henoch-Schönlein purpura (HSP) |
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serves an indispensable role in the NFATC1-regulated activation of CD4+ T cells and Th1 cell differentiation |
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is a heparin binding growth factor and is involved in neurogenesis, neural development and neuroprotection |
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may play a role in autism spectrum disorders (ASD) pathogenesis |
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MDK is responsible for increased plasma levels of vascular endothelial growth factor A (VEGFA), necessary and sufficient to promote endothelial cell proliferation in growing collaterals |
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role of midkine in endothelial proliferation are likely to be relevant for both, the process of arteriogenesis and angiogenesis |
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is a pleiotropic factor, which is involved in angiogenesis |
