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FLASH GENE

Symbol

PRL

contributors: mct/pgu - updated : 03-01-2023

HGNC name	prolactin
HGNC id	9445

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   has been described in relation to the pathogenesis and activity of several autoimmune disorders constitutional     --over   in decreased bone mineral density as well as in increased risk of fractures

Susceptibility

to breast cancer to increased adiposity in males

Variant & Polymorphism SNP	SNP rs4712652 near the PRL gene seems to affect body fat and adiposity in a sex-specific fashion

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular cardiomyopathy   inhibition of prolactin release by bromocriptine may represent a novel therapeutic strategy for postpartum cardiomyopathy neurology neurodegenerative Parkinson/dementia Parkinsonism promising molecule for the treatment of PD neurology neurodegenerative alzheimer promising molecule for the treatment of AD

ANIMAL & CELL MODELS

Prl is required for maintaining retinal functionality in both female and male mice during aging and has potential therapeutic value against age-related retinal disorders