| basic FUNCTION
| acting primarily on the mammary gland by promoting lactation |
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a role in regulating adipose tissue metabolism during lactation |
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induces estrogen receptor alpha and prolactin receptor expression |
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reduces the LPL activity in adipose tissues, via PRLR |
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responds to psychological stress |
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a role in bone/cartilage formation/repair processes |
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affects insulin binding and glucose uptake in adipocytes |
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involved in breast cancer through prolactin-induced receptor down-regulation mediated by proteasomes |
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plays a critical role in many steps of breast development |
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functions as a local regulator of various cell types in the mammalian retina  |
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important role for PRL in ovarian and endometrial tumorigenesis |
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decreases lipogenesis in adipose tissue as a consequence of suppressed malonyl-CoA concentration in parallel with decreased SLC2A4 expression |
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PRL present in the follicular fluid stimulates the proliferation of endothelial cells |
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prosurvival factor for human spermatozoa that prevents these cells from defaulting to an intrinsic apoptotic pathway associated with cell senescence |
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may play a role in the pathogenesis of antiphospholipid syndrome, especially antiphospholipid syndrome-related reproductive failure |
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promotes pubertal ESR1-dependent mammary ductal elongation and gene expression in the absence of estrogen, which are abrogated by the antiestrogen |
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PRL may be involved in the manifestation of insulin resistance |
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has pleiotropic functions in the brain |
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has a bioactive function acting as a hormone and a cytokine |
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interferes with immune system modulation, mainly inhibiting the negative selection of autoreactive B lymphocytes |
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has an important role not only in tumorigenesis of the breast, but also in a number of hormonally responsive cancers such as prostate, ovarian and endometrial cancer, as well as pancreatic and lung cancer |
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also impacts metastatic cancer of the breast to modulate the bone microenvironment and promote bone damage |
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PRL could be a crucial regulator in oocyte preimplantation and maturation |
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