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FLASH GENE
Symbol ITGA6 contributors: mct - updated : 23-04-2012
HGNC name integrin, alpha 6
HGNC id 6142
ASSOCIATED DISORDERS
corresponding disease(s) EBJPAA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in glioblastoma stem cells
tumoral     --over  
in precursor B-cell acute lymphoblastic leukemia
constitutional     --low  
identified transiently engrafting multipotent progenitors (MPPs)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbrainglioma/neuroblstoma
promising antiglioblastoma therapy
cancerreproductiveprostate
ITGA6 cleavage permits extravasation of human prostate cancer cells from circulation to bone and can be manipulated to prevent metastasis
cancerreproductivebreast
potential therapeutic target aimed at tumour-generating subsets of breast cancer cells
ANIMAL & CELL MODELS