Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ITGA6 contributors: mct - updated : 23-04-2012
HGNC name integrin, alpha 6
HGNC id 6142
DNA
TYPE functioning gene
STRUCTURE 78.87 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • laminin repressed transcription, directed by the promoter, by altering the nuclear levels of Sp1 and Sp3
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389058 2 similar to zinc finger protein Sp5 LOC285140 2q31.1 eukaryotic translation initiation factor 2 beta-like pseudogene LOC389059 2 LOC389059 LOC285141 2q31.1 similar to CG14853-PB GAD1 2q31 glutamate decarboxylase 1 (brain, 67kDa) GORASP2 2p24.3-q21.3 golgi reassembly stacking protein 2, 55kDa TLK1 8p22-p12 tousled-like kinase 1 FLJ13984 2q31.1 hypothetical protein FLJ13984 FLJ13096 2q31.1 hypothetical protein FLJ13096 MRPS29P2 2q31.2 mitochondrial ribosomal protein S29 pseudogene 2 LOC389060 2 similar to ribosomal protein S15 CYBRD1 2q31 cytochrome b reductase 1 LOC391460 2 similar to 60S ribosomal protein L21 DNCI2 2q24-q31 dynein, cytoplasmic, intermediate polypeptide 2 SLC25A12 2q24-q31 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 HAT1 2q31.2-q33.1 histone acetyltransferase 1 MAP1D 2q31.1 methionine aminopeptidase 1D DLX1 2q32 distal-less homeo box 1 DLX2 2q32 distal-less homeo box 2 ITGA6 2q22-q31 integrin, alpha 6 PDK1 2q31.1 pyruvate dehydrogenase kinase, isoenzyme 1 CGEF2 2q31 pyruvate dehydrogenase kinase, isoenzyme 1 ZAK 2q24.2 pyruvate dehydrogenase kinase, isoenzyme 1 LOC391461 2 similar to ribosomal protein S2; 40S ribosomal protein S2 CDCA7 2q31 cell division cycle associated 7 LOC344178 2q31.1 similar to peptidylprolyl isomerase A (cyclophilin A) LOC344181 2q31.1 similar to ribosomal protein L5; 60S ribosomal protein L5 SP3 2q31 Sp3 transcription factor LOC389061 2 LOC389061 LOC389062 2 LOC389062 LOC391462 2 similar to protein 40kD PTD004 2q31.1 hypothetical protein PTD004 LOC391463 2 similar to Leucine-rich repeat-containing protein 2 LOC389063 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 splicing 5680 122 1091 - 1991 2070796
  • a 23 amino acids signal peptide (2.3 kDa)
  • encoding the longest product
  • 26 splicing 5810 119 1073 - 1991 2070796
  • a 23 amino acids signal peptide (2.3 kDa)
  • containing an alternate exon resulting in a frameshift
  • shortest product with a distinct C-terminus
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
     mouthtongue  moderately
     stomach   highly
    Nervousnervecranial nerve  moderately
    Reproductivefemale systembreastmammary gland moderately
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE) lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text
  • embryonic tissue, placenta
  • upregulated in embryonic stem cells (hESCs) compared with mesenchymal stem cells
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 7 FG-GAP repeats domains
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Itga6 (92.45 pc)
    homolog to murine Itga6 (93.01 pc)
    Homologene
    FAMILY
  • integrin alpha chain family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text single-pass type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • mediating cell-extracellular matrix interactions also involved in the fertilization and embryonic development
  • distinct roles of ITGA6 and ITGA4 in homing of fetal liver hematopoietic stem and progenitor cells
  • major role in the proangiogenic properties of endothelial colony-forming cells (ECFCs)
  • regulates signaling pathways in a variety of cellular activities
  • cell-surface protein, having novel and dynamic roles in regulating the differentiation potential of mesenchymal stem cells and maintaining pluripotency
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of VLA-6 receptor
  • dimerizing with ITGB1 (laminin receptor) or ITGB4 (constituent of hemidesmosome)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • synergistic role for TAF4B and JUN and other AP1 family members on the promoter of ITGA6, underlining the existence of a specific mechanism related to gene expression control
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EBJPAA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma stem cells
    tumoral     --over  
    in precursor B-cell acute lymphoblastic leukemia
    constitutional     --low  
    identified transiently engrafting multipotent progenitors (MPPs)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    promising antiglioblastoma therapy
    cancerreproductiveprostate
    ITGA6 cleavage permits extravasation of human prostate cancer cells from circulation to bone and can be manipulated to prevent metastasis
    cancerreproductivebreast
    potential therapeutic target aimed at tumour-generating subsets of breast cancer cells
    ANIMAL & CELL MODELS