Symbol
| GLS
| contributors: mct - updated : 09-07-2015
|
HGNC name
| glutaminase
|
HGNC id
| 4331
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
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GLS silencing reduced proliferation of glioblastoma T98G cells and strengthen the antiproliferative effect evoked by previous GLS2 overexpression | tumoral
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| --over
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in colorectal cancer | tumoral
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| --low
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kills cells that overexpress MYC and catabolize glutamine | tumoral
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|  
| --over
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in hepatocellular carcinoma | |
Variant & Polymorphism
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Candidate gene
Marker
| GLS expression is a sensitive and specific biomarker for pathological diagnosis and prognosis of hepatocellular carcinoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | colon | |
may serve as a target for colorectal cancer therapy |
| | |