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FLASH GENE
Symbol GLS contributors: mct - updated : 09-07-2015
HGNC name glutaminase
HGNC id 4331
ASSOCIATED DISORDERS
corresponding disease(s) EIEE71 , CASGID
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
GLS silencing reduced proliferation of glioblastoma T98G cells and strengthen the antiproliferative effect evoked by previous GLS2 overexpression
tumoral     --over  
in colorectal cancer
tumoral     --low  
kills cells that overexpress MYC and catabolize glutamine
tumoral     --over  
in hepatocellular carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker GLS expression is a sensitive and specific biomarker for pathological diagnosis and prognosis of hepatocellular carcinoma
Therapy target
SystemTypeDisorderPubmed
cancerdigestivecolon
may serve as a target for colorectal cancer therapy
ANIMAL & CELL MODELS