basic FUNCTION
| catalyzing the first reaction in the primary pathway for the renal catabolism of glutamine |
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activity of GLS is directly regulated by RAF-MEK-ERK downstream of EGF receptor |
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neuronal glutaminase is a potential component of neurotoxicity during inflammation and modulation of glutaminase may provide therapeutic avenues for neurodegenerative diseases |
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metabolic enzyme responsible for glutaminolysis, a process harnessed by cancer cells to feed their accelerated growth and proliferation |
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mitochondrial enzyme that converts glutamine to glutamate |
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kidney-type isoform is associated with cell proliferation |
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GLS, NCALD and INSR are involved in nutrient signaling pathways and energy homeostasis suggesting a role in celiac disease pathogenesis |