Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

NACC1

contributors: mct/npt - updated : 14-03-2017

HGNC name	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
HGNC id	20967

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CEMRM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   by cocaine selectively in the nucleus accumbens, a CNS region important for drug addiction tumoral     --over   in ovarian serous carcinomas, higher in ovarian carcinoma cells in effusions compared with their solid tumor counterparts and several other types of carcinomas (Davidson 2007) tumoral     --over   in various carcinomas including ovarian, cervical, breast, and pancreatic carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	low expression of NACC1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary targeting of the BTB/POZ domain could be a therapeutic strategy for drug intervention in ovarian cancer and others cancer reproductive ovary regulates Taxol resistance in ovarian cancer and may provide an effective target for chemotherapeutic intervention in Taxol-resistant tumors

ANIMAL & CELL MODELS