basic FUNCTION
| cocaine-regulated POZ/BTB (Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex) protein, recruit histone deacetylases for transcriptional repression, further enhancing POZ/BTB protein mediated repression |
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contributes to tumor growth and survival by at least inhibiting GADD45GIP1 expression, which has a tumor suppressor effect in cancer cells (Nakayama 2007) |
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POZ-domain transcription factor that is involved in the self-renewal of embryonic stem cells (Stead 2009) |
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transcriptional regulator function of NACC1 was dependent on its nuclear localization activity in cells |
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transcriptional corepressor protein that is essential to sustain cancer cell proliferation and migration |
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participates in the coordinated proteolysis of synaptic proteins by mediating recruitment of the Ubiquitin Proteasome System (UPS) to dendritic spines |
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NACC1 may function to link TARDBP to the proteasome; thereby, facilitating the post-translational modifications of TARDBP that lead to the development of Amyotrophic Lateral Sclerosis (ALS) |
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down-regulates PRKN by presenting it for ubiquitin-dependent proteasome degradation, which causes a decrease in proteasomal activity in neuronal cells |
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cancer-associated BTB/POZ gene, that is involved in several cellular functions in neurons, cancer and stem cells |
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is a transcriptional repressor and protein binding factor, and probably functions in regulating neural development and network establishment by altering expression, localization, and degradation of many downstream nervous system genes |