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FLASH GENE

Symbol

TSC22D3

contributors: mct/npt/pgu - updated : 17-01-2014

HGNC name	TSC22 domain family, member 3
HGNC id	3051

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in synovial endothelial cells in rheumatoid arthritis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy   absence of TSC22D3/L-GILZ in skeletal muscle tissue enhances muscle regeneration and glucocorticoids might be more effective in the symptomatic treatment of dystrophy immunology inflammatory   Induction of GILZ expression in endothelial cells may represent a novel therapeutic modality with the potential to inhibit inflammatory leukocyte recruitment reproduction fertility   possible target for novel therapies to intervene in male sterility

ANIMAL & CELL MODELS

Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis development