basic FUNCTION
| being a candidate for a mediator of glucocorticoid-induced immunosuppression |
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can inhibit a variety of activation-induced events |
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protecting T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3 transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 |
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in macrophages, playing a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 |
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in T-cells, inhibiting anti-CD3-induced NFKB1 nuclear translocation |
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inhibits peroxisome proliferator-activated receptor gamma-2 (PPARG2) expression and blocks adipocyte differentiation |
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functioning as a modulator of mesenchymal stem cells and overexpression of TSC22D3 shifts the balance between osteogenic and adipogenic differentiation of mesenchymal stem cells toward the osteogenic pathway |
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with L-GILZ behave as modulators of myogenic differentiation, being able to inhibit myogenesis and to dampen the expression of differentiation markers such as MYHC and myogenin |
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involved in the regulation of myogenesis and mediate glucocorticoids-induced anti-myogenic activity |
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general inhibitor of FOXO factors acting through an original mechanism by preventing them from reaching target genes within the nucleus |
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aldosterone-induced chaperone, inhibiting SGK1 ubiquitinylation and subsequent proteasome-mediated degradation, thereby prolonging its half-life and increasing its steady-state expression |
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key role in controlling SGK1 protein stability and availability in specific subcellular compartments, thus selectively enhancing its regulation of a particular end point, in this case, Na+ transport |
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is a novel important factor for undifferentiated spermatogonia function and spermatogenesis |
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acts as an inhibitor of undifferentiated spermatogonia proliferation |
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its overexpression antagonized the inhibitory effects of TNF on mesenchymal stem cell osteogenic differentiation and the mRNA and protein expression of SP7 and RUNX2, two pivotal osteogenic regulators |
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essential role in mediating spermatogonial survival and spermatogenesis |
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role in maintenance of the male germline and spermatogenesis |
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anti-inflammatory protein first identified in T lymphocytes |
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its overexpression inhibits endothelial cell adhesive function through regulation of NFKB and MAPK activity |