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FLASH GENE
Symbol PHF14 contributors: SGE/npt - updated : 05-10-2015
HGNC name PHD finger protein 14
HGNC id 22203
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
respiratorylung 
target for the treatment of lung fibrosis
ANIMAL & CELL MODELS
  • Phf14-null mice show interstitial pulmonary hyperplasia and mesenchymal fibroblasts exhibit increased proliferation rates accompanied by enhanced expression of Pdgfra
  • depletion of Phf14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure