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FLASH GENE

Symbol

PHF14

contributors: SGE/npt - updated : 05-10-2015

HGNC name	PHD finger protein 14
HGNC id	22203

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Homo sapiens Skin/Tegument skin appendages hair follicle     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Homo sapiens Connective cartilage       Homo sapiens Epithelial secretory glandular endocrine   Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two PHD-type zinc fingers, tandem PHD structures
	a leucine-zipper (LZ) domain that is frequently observed in transcriptional factors involved in dimerization with other proteins carrying an LZ domain (pMID: 22730381)

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to Drosophila CG15439
	homolog to C.elegans Y59A8A.2
	homolog to murine Phf14 (97.3pc)
	homolog to rattus Phf14 (96.9pc)

Homologene

FAMILY

PHD protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be involved in the regulation of transcription, DNA-dependent
	regulates proliferation of mesenchymal cells
	plays a role not only in the process of lung organogenesis, but also in the induction of pulmonary fibrosis

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+ binding

protein

PHF14 acts as a negative regulator of PDGFRA expression in mesenchymal cells

cell & other

REGULATION

Other

phosphorylated upon DNA damage, probably by ATM or ATR

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed respiratory lung   target for the treatment of lung fibrosis

ANIMAL & CELL MODELS

	Phf14-null mice show interstitial pulmonary hyperplasia and mesenchymal fibroblasts exhibit increased proliferation rates accompanied by enhanced expression of Pdgfra
	depletion of Phf14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure