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FLASH GENE

Symbol

VANGL1

contributors: mct/npt - updated : 03-04-2015

HGNC name	vang-like 1 (van gogh, Drosophila)
HGNC id	15512

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral       gain of function in hepatocellular carcinoma constitutional germinal mutation       in sporadic or familial cases of neural tube defects tumoral     --over   increased glioma invasiveness and progression, associated with the up-regulation of EMT and stemness markers

Susceptibility

to neural-tube defects (NTDs)

Variant & Polymorphism other	V239I and R274Q asoociated to neural-tube defects (Kibar 2007)
	significant association between VANGL1 rare genetic variants, especially missense mutations, and NTDs risk

Candidate gene
Marker	might serve as a diagnostic marker for hepatocellular carcinoma
Therapy target
	System Type Disorder Pubmed cancer digestive colon targeting of VANGL1 can function as a chemotherapeutic strategy against colon cancer cancer digestive liver potential molecular target for development of novel therapeutic drugs

ANIMAL & CELL MODELS