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FLASH GENE

Symbol

RANBP9

contributors: mct - updated : 06-12-2014

HGNC name	RAN binding protein 9
HGNC id	13727

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   its overexpression reduces dendritic arbor and spine density constitutional     --over   in brains of patients with Alzheimer disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	promising therapeutic target for Alzheimer disease (therapeutic strategy might be to reduce RanBP9 levels and/or specifically disrupt its interactions with APP, LRP, and/or BACE1)

ANIMAL & CELL MODELS

most of Ran-/- mice die neonatally due to defects in the brain growth and development