protein
| binding RAN |
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associated with USP11 in the nucleus (is the enzymic substrate for USP11 and is deubiquitinated specifically) |
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interacting with the integrin LFA-1 |
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interaction between SPAG8 and RANBP9 may be involved in the process of male germ cell differentiation |
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ADAP1 and RANBP9 were shown to be involved in dendritic differentiation and RANBP9 could potentially act as a modulator together with ADAP1 in synaptic plasticity |
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interacting with CDK11, Met protooncogene, HIPK2, RAF1 |
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interaction with FMR1 in a CRA motif present in the RanBPM C terminus (modulation of the RNA-binding properties of FMR1) |
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interaction with MKLN1 |
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interacting with MKLN1 (subcellular localization of MKLN1 is coregulated by its C terminus, which provides a cytoplasmic restraint and also controls the interaction of muskelin with RANBP9) |
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strongly increased BACE1 cleavage of APP and Abeta generation |
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RANBP9 may modulate NTRK2-mediated downstream signaling and biological functions |
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YPEL5-binding protein |
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RANBP9 and TP73 have cooperative roles in inducing cell death, and the RANBP9/TP73 complex is implicated in mitochondria-mediated apoptosis in addition to its role in enhancing APP generation |
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RANBP9 appears to control brain growth and development through signaling mechanisms involving MAPK3 and L1CAM receptor |
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COPS5 is a RANBP9-interacting protein that robustly increases APP generation |
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acts as a negative regulator of LTB4R2 |
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RANBP9 was found to interact with HDAC6 and to inhibit its deacetylase activity |
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RANBP9-KAT5 interaction dramatically relocated RANBP9 from a widespread cellular distribution to nuclear speckles |