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FLASH GENE

Symbol

PTAFR

contributors: mct - updated : 10-03-2017

HGNC name	platelet-activating factor receptor
HGNC id	9582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	a lower expression of PTAFR correlated with poor differentiation and a poor prognosis, and may be used as a prognostic marker in hepatocellular carcinoma after hepatectomy
Therapy target
	System Type Disorder Pubmed cardiovascular     PTAFR antagonists, administered in combination with chemotherapy, may represent a promising strategy for cancer treatment

ANIMAL & CELL MODELS

Pafr(-/-) mice fed with high-refined carbohydrate-containing (HC) diet showed more steatosis, oxidative stress and higher transaminases levels associated with lower inflammation than WT mice