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FLASH GENE

Symbol

PTAFR

contributors: mct - updated : 10-03-2017

HGNC name	platelet-activating factor receptor
HGNC id	9582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Urinary kidney tubule     highly Homo sapiens Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor
	conserved proline in TM6 is crucial for intracellular trafficking of PTAFR
	seven hydrophobic regions interspersed with polar peptide segments, characteristic of rhodopsin-type G protein-dependent receptors

HOMOLOGY

Homologene

FAMILY

receptor,G protein coupled receptor superfamily

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus
text	presence of PAF receptor (PTAFR) at intracellular sites such as the nucleus

basic FUNCTION	platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity
	early Endothelial progenitor cell (EPC) express the PTAFR and respond to PAF signaling via a transient increase of cytoplasmic Ca(2+) concentration
	is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype
	PAFR signaling contributes to a pro-inflammatory environment in the model of obstructive nephropathy, favoring the fibrotic process, which lately will generate renal dysfunction and progressive organ failure
	in the absence of PTAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction
	nuclear PTAFR is responsible for the upregulation of unique set of growth factors, including vascular endothelial growth factor
	nuclear PTAFR translocates in an agonist-independent manner, and distinctive functions of PTAFR based on its cellular localization point to another dimension needed for pharmacologic selectivity of drugs

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

recognition of apoptotic cells by phagocytes leads to activation of PTAFR pathways, resulting in a microenvironment response favorable to melanoma growth

a component

INTERACTION

DNA

RNA

small molecule

protein

phagocytosis of apoptotic cells engages CD36 and PTAFR, possibly in lipid rafts, and this is required for optimal efferocytosis and the establishment of the macrophage regulatory phenotype

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	a lower expression of PTAFR correlated with poor differentiation and a poor prognosis, and may be used as a prognostic marker in hepatocellular carcinoma after hepatectomy
Therapy target
	System Type Disorder Pubmed cardiovascular     PTAFR antagonists, administered in combination with chemotherapy, may represent a promising strategy for cancer treatment

ANIMAL & CELL MODELS

Pafr(-/-) mice fed with high-refined carbohydrate-containing (HC) diet showed more steatosis, oxidative stress and higher transaminases levels associated with lower inflammation than WT mice