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FLASH GENE

Symbol

DNAJC3

contributors: mct - updated : 23-12-2013

HGNC name	DnaJ (Hsp40) homolog, subfamily C, member 3
HGNC id	9439

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

JDND

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function during virus infection to inhibit virus-induced apoptosis and inflammation to prolong host survival, even while prolonging viral replication

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in mice, loss of Dnajc3 leads to hyperglycemia and glucosuria associated with increasing apoptosis of pancreatic beta cells and reduced insulin levels