basic FUNCTION
| acting as an inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) |
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inhibits ER stress and plays an important role in maintaining balance and stability of the ER in retinal capillary endothelial cells (HRCECs) |
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defends cells against endoplasmic reticulum (ER) stress |
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ER molecular chaperone to maintain protein-folding homeostasis |
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act potentially as a co-chaperone, binding un- or misfolded proteins and delivering them to HSPA5 |
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plays a crucial role in ER protein folding and the UPR, thus adding evidence that dysfunctions in regulation of ER stress might serve as a common pathway linking diabetes mellitus and neurodegeneration |