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FLASH GENE

Symbol

LGI4

contributors: mct/npt - updated : 10-05-2017

HGNC name	leucine-rich repeat LGI family, member 4
HGNC id	18712

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LCCS12

Susceptibility

to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy

Variant & Polymorphism other	c.1914GC --> AT polymorphism, associated to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy (Gu 2004)
	c.1722G/A polymorphism might contribute to the susceptibility to BFIC

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology leukoencephalopathy   may be regarded as a novel therapeutic target to stimulate myelination

ANIMAL & CELL MODELS

Lgi4-deficient mice exhibited a more severe phenotype than claw paw mice and had gliogenic defects in sensory, sympathetic, and enteric ganglia