basic FUNCTION
| component of Schwann cell signaling pathway that controls axon segregation and myelin formation (Bermingham 2006) |
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regulated the functional maturation and structural pruning of glutamatergic synapses during postnatal development, and in postnatal developmental myelination of peripheral nerves (Zhou 2009) |
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novel functions for LGI4 regulating the proliferation and maturation of glial lineage cells throughout the PNS |
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is required for proliferation of glia in the peripheral nervous system and binds to a neuronal receptor, ADAM22, to foster ensheathment and myelination of axons by Schwann cells |
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identified as a new component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation |
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secreted protein that is required for Schwann cell development and differentiation |