Symbol
| POU2AF1
| contributors: mct - updated : 17-11-2015
|
HGNC name
| POU domain, class 2, associating factor 1
|
HGNC id
| 9211
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
| fusion
|  
|  
|  
|
with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231) | tumoral
| fusion
|  
|  
|  
|
with BTG4 in t(11;13)(q23;q12) in chronic lymphocytic leukemia | |
Susceptibility
|
to biliary cirrhosis |
Variant & Polymorphism
SNP
| rs4938534 is significantly associated to biliary cirrhosis |
|
|
Candidate gene
Marker
| may be helpful in the differential diagnosis of classical Hodgkin's lymphoma (cHL) and primary mediastinal B-cell lymphoma (PMBCL) (the highest positive predictive value for PMBCL were POU2AF1) | |
| Therapy target
| | |
| Bob1(-/-) mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection |