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FLASH GENE
Symbol POU2AF1 contributors: mct - updated : 17-11-2015
HGNC name POU domain, class 2, associating factor 1
HGNC id 9211
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with LAZ3/BCL6 in a B-cell leukemia cell line (Karpas 231)
tumoral fusion      
with BTG4 in t(11;13)(q23;q12) in chronic lymphocytic leukemia
Susceptibility to biliary cirrhosis
Variant & Polymorphism SNP
  • rs4938534 is significantly associated to biliary cirrhosis
  • Candidate gene
    Marker
  • may be helpful in the differential diagnosis of classical Hodgkin's lymphoma (cHL) and primary mediastinal B-cell lymphoma (PMBCL) (the highest positive predictive value for PMBCL were POU2AF1)
  • Therapy target
    ANIMAL & CELL MODELS
    Bob1(-/-) mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection