basic FUNCTION
| B-cell specific coactivator, involved in the response of B cells to antigens and required for the formation of germinal center and for normal transcription and v-(D)-J recombination of a subset of immunoglobulin Kappa genes |
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stabilizes POU dimer-DNA interactions |
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a clamp effect on the binding of POU2F1 monomer when it seems compromised |
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stimulates PORE activity |
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lymphoid-specific transcriptional coactivator that associates with the transcription factors POU2F1 or POU2F2 on the conserved octamer element present in the promoters of several ubiquitous and lymphoid-specific genes |
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transcriptional coactivator essential at several stages of B-cell development, critical for T helper cell function |
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regulates the balance of TH1 versus TH2 mediated immunity |
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novel role for POU2AF1 anf IKZF3 in controlling the transcription and nuclear organization of genes involved in pre-BCR function |
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B lymphocyte-specific transcription factor which coactivates POU2F1 and POU2F2 on B cell specific promoters |
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its tight regulation expression in early B cells is essential to allow efficient B lymphocyte differentiation |
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with POU2F2, are B-cell associated transcription factors expressed in a subset of patients with acute myeloid leukemia (AML) |
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POU2AF1 together with POU2F1/POU2F2, binds to octamer sites in promoters and enhancers to activate transcription of immunoglobulin (Ig) genes |
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B cell-specific transcriptional factor that coactivates octamer-binding transcriptional factors POU2F1, and POU2F2 on B cell-specific promoters |
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POU2F1 and POU2AF1 are selectively required for the in vivo generation of CD4(+) memory T cells |