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FLASH GENE

Symbol

TRIM5

contributors: mct - updated : 19-03-2020

HGNC name	tripartite motif-containing 5
HGNC id	16276

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to risk of HIV-1 infection

Variant & Polymorphism SNP	polymorphism may influence susceptibility to HIV1 infection (Javanbakht 2006)
	TRIM5 H43Y polymorphism is associated with a decreased risk of HIV-1 infection in the homozygote comparison and recessive model

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   introduction of two aminoacid substitutions, R332G and R355G, in the TRIM5 domain responsible for retroviral capsid recognition leads to efficient HIV-1 restriction upon stable over-expression

ANIMAL & CELL MODELS