| basic FUNCTION
| may act as an E3 ubiquitin ligase |
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potent inhibitor of infection by diverse retroviruses, modestly inhibits HIV1 strain carrying a mutation in the cyclophilin binding loop (Zhang 2006) |
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is an intrinsic immunity factor against HIV-1 infection, and arginine at 437 aa in SPRY domain for the late restriction is species-specific  |
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a single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5 |
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promotes innate immune signalling and that this activity is amplified by retroviral infection and interaction with the capsid lattice |
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retrovirus restriction factor TRIM5 blocks post-entry infection of retroviruses in a species-specific manner |
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novel function for TRIM5 as a pattern recognition receptor in innate immune recognition |
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TRIM5 blocks retroviral replication after cell entry, and species-specific differences in its activity are determined by sequence variations within the C-terminal B30.2/PRYSPRY domain |
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importance of TRIM5 recruitment to the Plasma membrane for TRIM5-mediated innate immune sensing and restriction of retroviral infection |
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specific cytoskeleton structures involved in TRIM5 innate antiretroviral defenses |
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TRIM5 acts as a selective autophagy receptor, and delivered its cognate cytosolic target, a viral capsid protein, for autophagic degradation |
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is an antiviral factor that can greatly limit HIV-1 infection |
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is an interferon-inducible retroviral restriction factor that prevents infection by inducing the abortive disassembly of capsid cores recognized by its C-terminal PRY/SPRY domain |
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in the absence of a restriction-sensitive virus, TRIM5 is degraded by both proteasomal and autophagic degradation pathways |
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link between TRIM5 and components of the autophagosome |
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is a RING domain E3 ubiquitin ligase with potent antiretroviral function |
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TRIM5 initiates innate immune signaling and orchestrates disassembly of the viral particle |
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is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA |
