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FLASH GENE
Symbol DIABLO contributors: mct/ - updated : 04-06-2015
HGNC name diablo homolog (Drosophila)
HGNC id 21528
ASSOCIATED DISORDERS
corresponding disease(s) DFNA64
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in mycosis fungoides (MF), the most frequent form of cutaneous T cell lymphoma
constitutional     --low  
alters both caspase-dependent and caspase-independent intrinsic programmed cell death
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
DIABLO mimetics can elicit a proinflammatory cell death that is sufficient to activate adaptive antitumor immune responses in cancer
ANIMAL & CELL MODELS