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FLASH GENE
Symbol DIABLO contributors: mct/ - updated : 04-06-2015
HGNC name diablo homolog (Drosophila)
HGNC id 21528
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Diablo (85.2pc)
homolog to rattus Diablo (85.7pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic
text released from mitochondria at entering the cytosol during apoptosis triggered by UV or gamma irradiation, cytotoxic drugs and DNA damage
basic FUNCTION
  • promoting apoptosis by binding to caspase inhibitors of the IAP family (BIRCS) and preventing them from inhibiting caspases
  • activating caspases in the cytochrome C/APAF1/CASP9 pathway
  • involved in TNF-mediated CASP8 activation and apoptosis
  • playing an essential role in the apoptosis induced by non-steroidal anti-inflammatory drugs in colon cancer
  • IAP-binding protein that is released from mitochondria during apoptosis
  • potentiating apoptosis by simultaneously antagonizing caspase-IAP interactions and repressing IAP ubiquitin ligase activities
  • one of the proapoptotic proteins released from the mitochondria that inactivate IAPs and play a redundant role during development and cell death
  • play an obligatory role in the tumor cells during several pathways of apoptosis induction
  • mitochondrial apoptogenic protein, mediating the proapoptotic function of BBC3 by regulating BBC3-induced mitochondrial events
  • playing an important role in executing DNA damage-induced and BBC3-mediated apoptosis and can participates in a feedback amplification loop to promote cytochrome c release and other mitochondrial events in apoptosis
  • can target BIRC2 to induce TNFalpha-dependent apoptosis and so may have a role in treating cancer
  • DIABLO function, but not Caspase-9 activity, was decisive for full effector caspase activation and clonogenic execution of Type I cells
  • acing potentially to enhance the early phase executioner caspase activity through the modulation of inhibitory interactions between specific IAP family members and executioner CASP3 and CASP7
  • plays key roles in both the diagnosis and treatment of cancer, especially lung cancer
  • in addition to APAF1 or apoptosome formation, DIABLO is also essential for MTCH1-induced apoptosis
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binding to the BIR domain of IAPs (XIAP and others) nad interacting with CASP9
  • TNF, MAPK8, BID, CASP8 for TNF-induced apoptosis
  • interacting with UBE2K (promoted degradation of mature DIABLO through the ubiquitin proteasome pathway)
  • PRPS1 initiates caspase activation upstream of cytochrome C and DIABLO
  • inhibits apoptosis of breast cancer cells by suppression of BIRC5
  • in apoptosis, BIRC5 recognize the DIABLO protein
  • BIRC6 may have a potential oncogenic role in neuroblastoma by inactivating cytoplasmic DIABLO
  • AREL1 interacted with and ubiquitinated IAP antagonists such as DIABLO, HTRA2, and PRPS1
  • IRF1 is critical dual regulator of DIABLO mimetic-induced apoptosis and inflammatory cytokine response
  • intramembrane cleavage of DIABLO by PARL generates an N-terminal IAP-binding motif, which is required for its apoptotic activity
    • cell & other
    REGULATION
    activated by caspases
    inhibited by BCL2
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA64
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in mycosis fungoides (MF), the most frequent form of cutaneous T cell lymphoma
    constitutional     --low  
    alters both caspase-dependent and caspase-independent intrinsic programmed cell death
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    DIABLO mimetics can elicit a proinflammatory cell death that is sufficient to activate adaptive antitumor immune responses in cancer
    ANIMAL & CELL MODELS