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FLASH GENE
Symbol PDE11A contributors: mct/pgu - updated : 18-12-2018
HGNC name phosphodiesterase 11A
HGNC id 8773
ASSOCIATED DISORDERS
corresponding disease(s) PPNAD2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   LOH   loss of function
of PDE11A4 in adrenocortical hyperplasia and Cushing syndrome, and patients with micronodular adrenocortical hyperplasia
constitutional       loss of function
in bilateral adrenocortical hyperplasia (BAH)
Susceptibility
  • to acromegaly
  • to prostatic cancer
  • Variant & Polymorphism other
  • variants in a subset of acromegalic patients, which was only slightly more frequent than in control (variants might only marginally contribute to the development of somatotropinomas)
  • PDE11A-inactivating genetic alterations may play a role in susceptibility to prostatic cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    PDE11A KO mice exhibit several subtle psychiatric-disease–related phenotypes indicative of ventral hippocampus dysfunction