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FLASH GENE

Symbol

PDE11A

contributors: mct/pgu - updated : 18-12-2018

HGNC name	phosphodiesterase 11A
HGNC id	8773

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PPNAD2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH   loss of function of PDE11A4 in adrenocortical hyperplasia and Cushing syndrome, and patients with micronodular adrenocortical hyperplasia constitutional       loss of function in bilateral adrenocortical hyperplasia (BAH)

Susceptibility

to acromegaly to prostatic cancer

Variant & Polymorphism other	variants in a subset of acromegalic patients, which was only slightly more frequent than in control (variants might only marginally contribute to the development of somatotropinomas)
	PDE11A-inactivating genetic alterations may play a role in susceptibility to prostatic cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

PDE11A KO mice exhibit several subtle psychiatric-disease–related phenotypes indicative of ventral hippocampus dysfunction