Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PDE11A

contributors: mct/pgu - updated : 18-12-2018

HGNC name	phosphodiesterase 11A
HGNC id	8773

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly Homo sapiens Reproductive male system prostate     predominantly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal GAF domain of the cytochrome C pseudogene, that vary in length and amino acid sequence, a tandem of so-called GAF domains in its N-terminal regulatory regions
	a GAF domain
	a conserved C-terminal catalytic domain that hydrolyzes cAMP and cGMP

HOMOLOGY

interspecies

homolog to Drosophila CG10231

Homologene

FAMILY	cyclic nucleotide phosphodiesterase family
	GAP/PDE family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	dual-specificity phosphodiesterase that binds both cAMP and cGMP that is expressed in adrenal cortex
	predispose to a variety of lesions (beyond micronodular adrenocortical hyperplasia) and may contribute to the development of these tumors in the general population
	may have a role in the pain pathway of migraine as well as trigeminal neuralgia and trigeminal autonomic cephalalgias
	plays a significant role in regulating brain function
	genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

by tadalafil partially

ASSOCIATED DISORDERS

corresponding disease(s)

PPNAD2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH   loss of function of PDE11A4 in adrenocortical hyperplasia and Cushing syndrome, and patients with micronodular adrenocortical hyperplasia constitutional       loss of function in bilateral adrenocortical hyperplasia (BAH)

Susceptibility

to acromegaly to prostatic cancer

Variant & Polymorphism other	variants in a subset of acromegalic patients, which was only slightly more frequent than in control (variants might only marginally contribute to the development of somatotropinomas)
	PDE11A-inactivating genetic alterations may play a role in susceptibility to prostatic cancer

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

PDE11A KO mice exhibit several subtle psychiatric-disease–related phenotypes indicative of ventral hippocampus dysfunction